Metabolic stability assays

Record Type: Evaluation

Studies measure compound half-life, calculate intrinsic clearance and predict human pharmacokinetic (PK) profiles in anticipation of first-in-human (FIH) trials. 

Disappearance of a parent compound or the appearance of metabolites is measured following incubation with hepatocytes, liver microsomes or plasma, enabling calculations of half-life and intrinsic clearance.

Biotransformation of test article and metabolite profiles can then be elucidated.

 

Molecule or Product Type

Small Molecule, Biologics

Regulatory

IND & CTA

Industry Market

Pharma

Phase

Nonclinical