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Access comprehensive services for antimicrobial development, including a wide range of validated in vivo models complimented by full in vitro support. Have a custom need? We are happy to collaborate to develop and validate bespoke models tailored to your criteria. We also offer stand-alone in vitro assays to investigate efficacy against a wide range of bacterial and fungal pathogens. With expertise in efficacy models, pharmacokinetic (PK) models, and safety models, you can count on quality studies with accelerated data delivery.
In vivo models of infection:
- Infection du poumon à Aspergillus, souris
- Sepsis à Candida Albicans, souris
- Virus de l'hépatite B (VHB), souris
- VHB-AAV, VHB/VHD, VHB mutant
- Modèle de souris chimérique du foie humain infecté par le VHB (souris PXB®)
- Grippe (H1N1), souris/furet
- Modèle d'infection de la cuisse neutropénique à Staphylococcus aureus résistant à la méthicilline (SARM), rat
- Infection pulmonaire à Pseudomonas aeruginosa, souris
- Infection du poumon à virus respiratoire syncytial (VRS), souris
- Infection du poumon à Streptococcus pneumoniae, souris
- Streptococcus pneumoniae sepsis model, mouse
In vivo study support services:
- Preparation of bacterial/viral/fungal infective doses, including agar bead prep for bacterial and fungal respiratory models
- Organ/tissue bioburden counts
- Viral titre assays (CPE assay, Plaque assay)
- Bacteriophage plaque assays
In vitro antimicrobial efficacy:
- In vitro Minimum Inhibitory Concentration (MIC) assays
- Aerobic/anaerobic bacteria and fungal pathogens (Hazard class 2)
- Antibiotic resistance/susceptibility testing
Non-animal model for assessment of acute toxicity and antimicrobial efficacy:
- Galleria mellonella wax moth larva model - TruLarvTM
