Oncologie préclinique

When your research has the potential to save lives, you deserve a partner with the oncology pharmacology knowledge, breadth of tools and experience to move life-changing drug candidates through non-GLP, preclinical development and oncology clinical trials quickly and efficiently.  

We've helped hundreds of companies discover their next life-improving compound. 

Browse hundreds of cell line growth curves in our complete cell line list or read our spotlights on tumor models. 

We offer over 30 different syngeneic tumor models, from both solid and disseminated origins, to provide you with many choices to further your immuno-oncology research. We are continually improving and expanding adoptive cell therapy capabilities:

• Immuno-oncologie
• Thérapies cellulaires adoptives 

For over a decade, we have offered an industry-leading array of in vivo imaging modalities for optimum pharmacologic interrogation when needed. Parmi celles-ci :

• Cytométrie en flux 
• Imaging 
• Radiation

LL/2 : un modèle de tumeur murine immunosuppressive

Le cancer du poumon est le deuxième cancer le plus couramment diagnostiqué chez les hommes et les femmes aux États-Unis et c'est, de loin, la cause la plus fréquente de décès des suites d'un cancer chez les hommes et les femmes. In 2019, the American Cancer Society estimates that 228 150 new cases of lung cancer (116 440 in men and 111 710 in women) will . . . Read more about the LL/2 model

B16-F10 : un modèle de mélanome murin

Les cancers de la peau comprennent des carcinomes de toutes les couches de la peau, les plus communs étant le carcinome basocellulaire (CBC) et le carcinome à cellules squameuses (CCS). Melanoma and non-melanoma skin cancers (Merkel cell carcinoma, Kaposi sarcoma, cutaneous lymphoma and other sarcomas) are much less common. . . . Read more about a murine melanoma model

Preclinical Models of Multiple Myeloma

Multiple myeloma is a clonal B cell malignancy characterized by the accumulation of terminally differentiated, antibody-producing plasma cells in the bone marrow that is invasive and drug resistant. Patients are generally asymptomatic until very late state disease. There are few preclinical models that recapitulate human disease. In this work, we have evaluated the human MM.1S model and the murine 5TGM1 model . . . Read more about the preclinical models of multiple myeloma

Caractérisation en profondeur des cellules myéloïdes dans le modèle syngénique murin de carcinome du côlon CT.26 par cytométrie en flux à 10 couleurs

The efficacy of immune-modulating anti-cancer therapeutic antibodies that have been FDA-approved in recent years, such as anti-CTLA-4 and anti-PD-1, has driven growing interest in methods that provide a mechanistic understanding of drug function. . . Read more about In-Depth Myeloid Cell Characterization

• AACR | 24-29 April | San Diego, CA
• Nonclinical Drug Symposium | 6-7 May, Germany