La radiation focale favorise le traitement par paclitaxel dans un modèle murin du cancer du sein triple négatif


Maryland Rosenfeld Franklin, Thomas Dailey, and Wilbur R. Leopold



Réunion annuelle de l'AACR

“Focal Radiation Enhances Paclitaxel Therapy in a Mouse Model of Triple Negative Breast Cancer”


Introduction & Background:

  • Triple negative breast cancer (TNBC) accounts for 15-20 % of all breast cancers in theUnited States.
  • Patients with TNBC have poorer prognosis and therapeutic intervention is more challenging due to insensitivity to
  • hormonal and anti-HER2 therapies.
  • Therapeutic options for TNBC can include chemotherapy and/or radiation (RT) treatment.
  • Clinical trials evaluating shorter, hypofractionated doses of radiation are being conducted in patients with breast cancer.
  • This study evaluated preclinical activity of paclitaxel in combination with either lower dose, more frequent radiation or higher dose, less frequent radiation.